The story revolves around a group of people who were not connected to each other in any way other than by ill-fate. These were people from different parts of India who had travelled to the US and now were boarding the ill-fated flights that crashed into the Twin Towers and Pentagon in New York on 9/11/2001. The story tells us about the horror of the hijack and some of the incidents that occurred on board during those horrific minutes. Some of the characters in the film die in the attacks.

• Tilottama Das-Punj (Konkona Sen Sharma) is happily married to the man of her dreams, Hemant (Jimmy Sheirgill), whom she met online. However, their time together is cut short when Hemant is needed in the U.S. to attend to his job. Tilottama is left at home with her mother-in-law who makes sure that she does not keep in touch with him. Tilottama goes to extreme lengths to join him in USA.
• Salim Rajabali (Irrfan Khan) is the rich son of a powerful godmother. He is captivated by the much older Namrata (Suhasini Mulay). Unfortunately he gets involved in a murder and finds out that Namrata has been cheating on him. Before the situation gets out of hand, his mother (Saroj Khan) tells him to flee the country.
• Poor yet academically brilliant Rahul Bhide (Ankur Khanna) is over the moon when he receives an offer to study at a prestigious university abroad. But his excitement is short lived by the lack of funds and also due to his incapacitated father. Just when he gives up hope, he receives funding with the help of his friend Khushboo (Ayesha Takia) and looks forwward to a bright future abroad.
• Rajubhai Patel (Paresh Rawal) is an event organizer for prestigious and popular foreign shows. His ex-girlfriend Tara (Ratna Pathak Shah) mortgages her house to pays for his daughter Payal (Shahana Goswami) to be taken abroad along with him.

• Konkona Sen Sharma... Tilottama Das - Punj
• Irrfan Khan ... Salim Rajabali
• Ayesha Takia ... Khushboo Modi
• Jimmy Sheirgill ... Hemant Punj
• Paresh Rawal ... Rajubhai Patel
• Saroj Khan ... Amma, Salim's mother
• Ratna Pathak Shah ... Tara Gandhi
• Ankur Khanna ... Rahul Bhide
• Boman Irani ... DCP Paul
• Suhasini Mulay ... Namrata
• Imaad Shah ... Joy
• Shahana Goswami ... Payal, Tara's daughter
• Sameer Sheikh ... Nitin
• Meghna Malik .... Kalpa
• Ravi Baswani .... Papaji, Hemant's father
• Tinu Anand .... Dhiroobhai
• Rajat Kapoor .... U S Consulate Officer
• Karan Khanna ....Javed Rajabali
• Trishla Patel ....Natasha
• Ranvir Shorey ....Sports Bar Manager
• Makarand Deshpande .... Dom at cremation ground (in a friendly appearance)
• Karla Singh .... Carren Punj, Hemant's mother
• Utkarsh Majumdar .... Hirji
• Suhas Bhalekar .... Bhide, Rahul's father (in a friendly appearance)
• Guzby Walia .... Minal
• Ahmed Khan .... Minal's father
• Anupam Shyam .... Inspector Ranade
• Ruchi Pugalia .... Javed's wife
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