Rishi (Ritesh Deshmukh) and Anju (Genelia D'Souza) are childhood buddies. They were born on the same day, in the same hospital. Even their parents are best friends from their college years and are now neighbours. Rishi and Anju are inseparable, so much so that they study in the same college in the same class.

Akash (Raja Bherwani), a very talented singer, develops feelings for Anju when she spontaneously sings with him at a college function. He, Anju and others leave for Bangalore for a week to participate in a few inter-college competitions. As they are apart for the first time in their lives, Rishi starts missing Anju very badly, but does not understand his feelings. His maid Sarro (Supriya Pilgaonkar), who often teases him and Anju, starts teasing him that he is missing her because he loves her. Slowly, with the maid's words, Rishi begins to realise that he loves her. He buys a gift and greeting card to express himself when she returns. Meanwhile, he sees a girl from his college slapping her friend because he said he loves her. She in a distressed mood and says that such guys are a shame to friendship as they pretend to be friends but really have other intentions. She wishes that every guy could be like Rishi so that a girl and guy could be best friends without any worries. Rishi then feels that he should not tell Anju about his feelings lest she, too, react the same way. He feels that he can bear not to tell her about his love but cannot imagine losing her friendship.

Anju returns from Bangalore and tells Rishi that Akash proposed to her during their stay. She comes to his room to ask him what to reply and by mistake half opens the drawer in which he kept his greeting card and gift. He hurriedly closes it and asks her not to open it then tells her to agree to the proposal if she likes Akash. She agrees to his proposal. Later things start to get a rough as Akash doesn't like the closeness Rishi and Anju share. When Akash and Anju are having a conversation and Rishi joins them, Akash asks him to leave as they need some privacy. Such actions greatly distress Anju and she warns him not to do it again, but Rishi explains that what Akash is doing is justifiable.

Akash's grandmother comes to Anju's house to arrange their marriage. Her parents agree and marriage preparations are well underway. It is decided that after marriage, Anju will leave with Akash to the USA where his family is settled. It is then that she realises this marriage means breaking her relationship with Rishi and leaving forever. She suddenly dislikes getting married and tries to talk to Rishi about it, but he casually says that it is all part of life and inevitable. She asks how can he talk so cold heartedly. She says she wishes she did not have to leave and wonders why she had to love Akash. She scolds him why he did not get the idea to love her in the first place. At this point Rishi, overcome by emotion, hugs Anju, cries and runs away from her.

Anju grows suspicious of his actions and remembers the drawer that he did not let her open. She goes to his room and is shocked to find the card and gift. She says that she does not want to marry Akash and will tell everyone about them. Rishi firmly refuses saying that their parents have given them unlimited freedom: It would be very hurtful, selfish and irresponsible of them to break their trust.

At his insistence she goes through the engagement ceremony. After the engagement, Rishi says that he has to go to a basketball match out of the state and will not be there for the marriage. The parents try to convince him, but he doesn't listen. Anju gives him a ride to the station and on the way they remember their childhood. At the station as Rishi is climbing aboard Anju weeps and holds him. He is unable to leave. At the house, the maid tells their parents everything and they come to the station. They find Anju and Rishi on the platform stairs and say that what they feel is not wrong, and it is the way of the world. They say that they shall cancel the marriage and ask them to come home.

• Ritesh Deshmukh as Rishi
• Genelia D'Souza as Anjali, aka Anju
• Raja Bherwani as Akash
• Shriya Saran as Girija
• Supriya Pilgaonkar as Sarro
• Satish Shah as Satish Kanna, Anju's father
• Umesh Tonpe as Rishi's College Friend
• Sushma Seth as Akash's Grandmother
• Shakti Kapoor as Kailash, Rishi's father
• Supriya Karnik as Rohini, Rishi's mother
• Jaspal Bhatti as Sardarji
• Asrani as Kashinath Dixit, Akash's father
• Chandan Kumar as Rishi's friend
• Suvendu Bal as stage singer
• Amit satpathy as Bhakad sai baba
• Girija Shettaras herself, special appearance
• Bipasha Basuas Girija, special appearance

• Raju Pandit
• Priteee Pandit
• Yuvraj Raut

All lyrics written by Mehboob; all music composed by Viju Shah.

Vilasrao Deshmukh's son, Ritesh, was making a Bollywood debut and the minister with his Mantralaya officials was doing his bit to make Tujhe Meri Kasam rock at the box office.

From CM's public relations officials to his congressmen, from party activists to police inspectors and ward officers were reportedly roped in for the star-studded premiere at the IMAX dome in Wadala, Mumbai. While cable TV operators were warned against showing pirated versions of the movie, television promos and the many billboards in the city made sure that it did not go unnoticed. Most say that all these hoardings were not funded by the film's producer. If this wasn't enough, the chief minister used his powerful influence to get the who's who to attend the grand premiere. It was then that Deshmukh was asked to resign citing reason that he employed political machinery for such an affair.