Three contestants were each given a bingo-style card with 15 numbers, arranged in three rows of five, and competed to fill in all the numbers. One contestant had the numbers 1-15, the second had 16-30, and the third had 31-45. These numbers were also used in an audience game, described below.

Round one

Four categories were displayed, each containing four questions, and the winner of a random backstage draw chose one to start the round. The host read a toss-up question; if a contestant buzzed-in with the correct answer, the number in one corner of his/her card was filled in and he/she chose the next category. An incorrect buzz-in answer froze the contestant out of the next question, whose category was chosen by the host.

The first person to fill in all four corners won $750, which was his/hers to keep regardless of the game's outcome.

Round two

The contestants were each given a Trump Card. After giving a correct answer, a contestant could play the Trump Card to impede the progress of one of the his/her opponents. That contestant would have his/her card blocked with a giant letter T, which could only be removed with a correct answer.

Four new categories were displayed, each containing five questions, and the winner of round one chose first. Gameplay proceeded as in round one, but every correct answer now filled in a number on the middle row of the contestant's card. The first contestant to complete his/her row won $1,500.

Round three

This round consisted of rapid-fire general knowledge questions, and every correct answer filled in one of the remaining numbers on the contestant's card. An incorrect response froze him/her out of the next question as before. The first contestant to complete his/her card won $3,000 and advanced to the bonus round. If time was called before this happened, the contestant who had the most numbers filled in and was not hindered by a Trump Card was declared the winner. In the event of a tie, an all-or-nothing tossup was asked of the tied contestants; answering correctly won the game while an incorrect answer gave the victory to the opponent.

The numbers 1 through 25 were displayed on a 5-by-5 grid. The champion drew one card from a deck of 25, and the space with the chosen number was filled in. He/she drew a second card if he/she had not used the Trump Card during the main game.

The champion then had 45 seconds to complete a horizontal, vertical, or diagonal line of five spaces by answering general knowledge questions. He/she chose a space, and the host asked a question. A correct answer filled in the space, but a pass or miss blacked it out. Completing a line before time ran out awarded $10,000 on top of whatever the champion won in the main game; a winning contestant on Trump Card could win up to $15,250 in one match.

Three new contestants competed on each episode.

Audience members were each given their own double-sided cards. The front of each card followed the pattern of those used by the contestants. When a contestant answered a question correctly and filled in a number, audience members could mark it off on their cards as well. Any member who reached the goal of a round before the contestants won $10; this payout could be collected in one, two, or all three rounds, for a maximum of $30.

The other side of the card had a 3-by-3 grid of nine numbers to be used in the bonus round. If the number drawn by the champion appeared on this grid, the audience member's winnings were increased by 50% (e.g. from $20 to $30). If the champion drew a second number due to saving his/her Trump Card, and this number also appeared on the grid, the member's winnings were doubled (e.g. from $20 to $40). Members marked off numbers as the contestant gave correct answers, and any member who completed a line of three had his/her entire winnings total doubled.

Audience members could win up to $120, by winning $10 in each of the three rounds, doubling the money with two matching draws in the bonus round, and doubling again by completing a line of three numbers.

Trump Card ended its first and only season with a tournament of champions. Twenty-one bonus round winners were invited back to compete for a shot at an additional $100,000.

Seven preliminary matches were played with winners receiving $3,000, but no additional money awarded for winning either of the first two rounds. The bonus round was still played, with the same $10,000 prize awarded. The best preliminary winner proceeded directly to the final match; the other six winners played in two semifinal matches, with the winners advancing to the finals. The final match was played for $10,000, with the runners-up each receiving $2,500.

The winner of the final match then played the bonus round one final time. This time, he/she was given a choice of three different question packets to choose from before the game began. After choosing the packet and his/her free space(s), the round was played as it normally would be; the only difference was that if the tournament winner successfully completed it, his/her match winnings would be multiplied by ten for a total of $100,000. The prize went unclaimed, however, as the tournament winner was unable to complete the bonus round successfully.