• The Killer (1921 film), an American western film directed by and starring Jack Conway (filmmaker)
• The Killer (1953 film), a Turkish adventure film
• Killer! (1969 film), an alternative title for This Man Must Die
• The Killer (1972 film), a Hong Kong film produced by Shaw Brothers Studio
• The Killer (1989 film), a Hong Kong action and crime film directed by John Woo and starring Chow Yun Fat
• Killer (1991 film), a Telugu film starring Akkineni Nagarjuna
• Killer (1994 film) (a.k.a. Bulletproof Heart), a film starring Anthony LaPaglia and Mimi Rogers, and featuring Peter Boyle
• Killer: A Journal of Murder, a 1996 film about serial killer Carl Panzram
• Killer (1998 film), a French/Kazakhstani crime drama
• Killer: Dead or Alive, a 2006 thriller film
• The Killer (2006 film), a Bollywood film starring Emraan Hashmi and Irrfan Khan
• Le Tueur (English: The Killer), a French film directed by Cédric Anger, released in 2007
• The Killer (2007 film), a horror short starring Michael Learned
• The Killer (2017 film), a Brazilian film
• "Killer" (Taggart), the 1983 pilot episode and title of the later renamed Scottish detective TV series Taggart
• "Killer" (CSI), an episode from the sixth season of the American television series CSI: Crime Scene Investigation (2006)
• "The Killer" (The Vampire Diaries), an episode of the television series The Vampire Diaries
• Ghostface (Scream), aka "The Killer" - the murderer in the Scream movie series
• Killer (Home and Away), a character from Home and Away
• Killer Kane, the villain of the 1939 Buck Rogers film serial

• Killer: A Journal of Murder (novel), a 1970 biographical novel upon which the 1996 film is based
• The Killer (1970 novel), a novel by Colin Wilson
• The Killer, a 1933 novel by Walter B. Gibson about the fictional character The Shadow
• The Killer (Perera novel), a novel by Lishan Perera
• Killer (novel) a novel by Sara Shepard, part of The Pretty Little Liars series
• "The Killer" (story), a short story by Stephen King

Bands

• Killer (Finnish band), an early 2000s Finnish alternative and experimental rock band
• Killer (Swiss band), a hard rock band
• Killer (Belgian band), a hard rock band

Albums

• Killer (Alice Cooper album), a 1971 rock album by Alice Cooper
• Killer (Tech N9ne album), 2008 rap album by Tech N9ne
• The Killer (Impious album), a 2002 album by Impious

Songs

• "Killer" (Kiss song), 1982
• "Killer" (Adamski song), 1990
• "Killer" (Fazer song), 2012
• "The Killer" (Mobile song), a song by Canadian band Mobile
• The Killer (Shed album), a 2012 album by German techno musician Shed
• "Killer", a song by Van Der Graaf Generator from H to He, Who Am the Only One, 1970
• "Killer", a song by Boy Kill Boy from Civilian, 2006
• "Killer", a song by The Hoosiers from The Trick to Life, 2007
• "Killer", a song by Krokus from Painkiller, 1978
• "Killer", a song by Kali Uchis from Isolation, 2018

Other

• Killer (video), a music DVD by Die Ärzte released in 1999

• Killer (pool), a multi-player pocket billiards (pool) game
• Killer, a climbing card game related to ti?n lên
• Killer (game), a parlor game played with cards and candles
• Assassin (game), or killer, a live-action role-playing game
• Killer: The Game of Assassination, a live action role-playing game set of rules first published by Steve Jackson Games in 1982
• Killer, a variant of the game of darts
• Killer sudoku, or samunamupure, a variant of sudoku

• Killer (nickname), a list of people known as "Killer" or "The Killer"
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