The film revolves around the story of three women.

Zia (Bhumika Chawla), who is a fast rising Bollywood actress, whose live-in relationship is about to break up with the man who has groomed her for a film career, Neel (Rahul Bose). She wants a child with him but he does not want any responsibilities. Soon he moves on and finds another girlfriend. Divya Dutta features in a pivotal supporting role.

Anushka (Riya Sen) is a telephone receptionist who longs to discover tenderness in her relationship with a wealthy suitor Nikhil (Ashmit Patel). Meanwhile, her office colleague, Tarun (Jimmy Sheirgill), loves her silently. The working girl must decide between the two in a romantic finale that has a twist in the tale. Natassha features in a role that has a big impact. The three stories are weaved into a composite picture, with the women coming together in an act of solidarity.

Rehana (Tabu) is a housewife who must confront the fact that her husband Anwar (Kay Kay Menon) is being unfaithful to her with an air hostess, Preeti (Celina Jaitly).

Story 1

• Bhumika Chawla as Ziya Rao
• Rahul Bose as Neil Kashyap
• Divya Dutta as Diya Rao
• Priya Badlani as Nandita
• Aamir Ali as a Bollywood actor
• Tabu as Ziya's fan

Story 2

• Riya Sen as Anushka
• Jimmy Sheirgill as Tarun
• Ashmit Patel as Nikhil
• Anita Hassanandani as Piya

Story 3

• Tabu as Rehana
• Kay Kay Menon as Anwar
• Celina Jaitley as Preeti
• Karan Panthaky as Inayat (Anwar's son from his first wife)
• Priya Badlani as Nandita (Preeti's friend)

Other cast

• Shah Rukh Khan as the Sutradhaar (Narrator)
• Dolly Bindra as Ziya's fan / Woman at the beach / Sheetal
• Rakesh Bedi as Harry (Nandita's uncle) / Anushka's boss

Music by Himesh Reshammiya & Lyrics by Sameer

Taran Adarsh of Bollywood Hungama panned the film saying, "Silsilay is more of an experiment that caters to a very small segment of moviegoers. At the box-office, the film holds no appeal for an ordinary cinegoer."^[3]