• Saira Ahmed al-Said (born 1989), a mathematician and Sheikha, wife of Sheikh Al-Said
• Saira Elizabeth Luiza Shah (1900–1960), a Scottish writer who wrote under the pen name Morag Murray Abdullah
• Saira Shah (born 1964), an author, reporter and documentary filmmaker
• Saira Banu (born 1944), actress and the daughter of a well-known actress, the granddaughter of the famous playback singer, and the wife of an actor
• Saira Khan (born 1970), the runner-up on the first series of The Apprentice in Great Britain
• Saira Wasim (born 1975), a noted contemporary artist from Lahore, Pakistan
• Saira Mohan (born 1978), a Canadian fashion model of Indian, French and Irish descent
• Saira Choudhry (born 1988), an English actress, most notable for her role as Anita Roy in the Channel 4 soap Hollyoaks
• Saira Blair (born 1996), elected to the West Virginia State House of Representatives in 2014, at the age of 18.
• Saira Todd, British actress, Lisa Levene in Queer as Folk (UK)
• Saira Khatri, (born 2005), raised in Texas, is a young girl who strives to be a professional Youtube and Netflix watcher.

• Saira Batra, General Hospital: Night Shift character

Saira is short for Sahira meaning enchantress, magician, princess in Urdu.

• Cololabis saira, the scientific name of the Pacific saury fish
• Saira (film), a 2005 Malayalam Language Indian film starring Navya Nair and Nedumudi Venu
• Saira (video game), a computer game developed by Nifflas in 2009