Rocco or Rocko is both a given name and a surname. Notable people with the name include:
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- Saint Roch or Rocco (c. 1295-1327), Christian saint
- Rocco Baldelli (born 1981), American Major League Baseball player and coach for the Tampa Bay Rays
- Rocco Botte (born 1983), American actor and filmmaker
- Rocco Buttiglione (born 1948), Italian politician
- Rocco Chinnici (1925-1983), Italian magistrate killed by the Mafia
- Rocco Rocky Colavito (born 1933), American retired Major League Baseball player
- Rocco DiSpirito (born 1966), American celebrity chef and reality show actor
- Rocco Fischetti (1903-1964), American mobster
- Rocco Landesman (born 1947), Broadway producer
- Rocco Mediate (born 1962), American golfer
- Rocco Milde (born 1969), German former footballer
- Rocco Perri (1887-last seen 1944), Canadian bootlegger
- Rocco Petrone (1926-2006), Italian-American engineer and NASA executive
- Rocco Placentino (born 1982), Canadian soccer player
- Rocco Pozzi (1700-1780), Italian painter and engraver
- Rocco Quinn (born 1986), Scottish footballer
- Rocco Rossi (born 1962), Canadian politician
- Rocco Siffredi (born 1964), Italian pornographic film actor
- Rocco Silano (born 1962), American magician and actor
- Alex Rocco (1936–2015), American actor
- Alfredo Rocco (1875-1935), Italian jurist and Fascist politician, author of the Italian Penal Code
- Danny Rocco (born 1960), American college football head coach
- David Rocco (born 1970), Canadian actor and producer, host of David Rocco's Dolce Vita
- Keith Rocco, contemporary American military painter
- Lyla Rocco (1933–2015), Italian film actress
- Marc Rocco (1962-2009), American film director, producer and screenwriter
- Mickey Rocco (1916-1997), American Major League Baseball first baseman
- Nereo Rocco (1912-1979), Italian football player and manager
- Pasquale Rocco (born 1970), Italian retired footballer
- Steve Rocco (born 1960), American skateboarder and retired businessman
- Steve Rocco (politician), contemporary American politician