Shamsher Singh (Anil Kapoor) owns a private island Al-Shifa for trading arms and narcotics. Sikander Singh (Salman Khan) is Shamsher's step son, while Sanjana (Daisy Shah) and Suraj (Saqib Saleem) are his twin children. Yash (Bobby Deol) is a close associate at Shamsher's empire and Sikander's confidante. In a flashback scene, it is revealed that Rana Vijay (Freddy Daruwala) is Shamsher's business rival and he creates problems for Shamsher's family business. As both Sanjana and Suraj age to 25 years, their family lawyer explains the will of their deceased mother (Nishigandha Wad). As per the will, the twins are entitled for 25% share each, and the rest 50% for Sikander. This visible disparity causes the twins to begin hating Sikander. Shamsher tells both of them that Sikander is the son of his elder brother Ranchor Singh (Milind Gunaji).

In a flashback, that portrays the Handia village of the 1970s, the history of the Singh family is depicted. Both the Singh brothers used to supply weapons to Indian army. Local politicians of Handia asked them for illegal weapons to which Ranchor refused. His refusal caused rivalry with a local politician. One day, during an ambush on Shamsher's truck, Vijendar Singh's (Manav Vij) son (Anurag Arora) was killed by Ranchor's gunshot. One day, Ranchor died when his car was exploded by a bomb. The Singh family was then sought to be as a legitimized anti-state and accused of supplying weapons to enemies. Shamsher sends Sikander to Beijing for studies and takes Suraj, Sanjana and their widowed mother to Cambodia.

Back to present day Al-Shifa, one night, Yash talks about his girlfriend. Sikander reveals that in Beijing he fell in love with a girl named Jessica (Jacqueline Fernandez) who severed him. Shamsher's childhood friend Brijmohan (Rajesh Sharma) tells him that his friend's hotel was used by politicians for their lascivious motives where all the activity was captured on a spy video camera and stored on a hard disk. The hard disk was kept at a bank's locker in Cambodia. Shamsher appoints Sikander for the recovery of the hard disk, and he promises him to get back the disk. The next day, during a party it is revealed that Jessica was actually Yash's girlfriend. Sikander and Jessica meet privately in the security room. The very next day, Suraj and Sanjana, who had recorded the Sikander-Jessica meet, screen the video to Yash. A furious Yash goes to Jessica's apartment and finds Sikander present with her. Sikander later tells him that both of their past interactions with Jessica were planned by Suraj and Sanjana, as part of their plan to destroy Sikander. Yash teams up with Sikander against the twins but pretends to be with the twins as well. Sikander, the twins, Yash and Jessica execute the mission to recover the hard disk.

After retrieving the hard disk, Shamsher eliminates Sikander by planting explosives in Sikander's car and heads to a conference with the politicians whose objectionable videos were stored on the disk. Shamsher tells about Sikander's death to the politicians, in the presence of the twins. He then plugs the hard disk and is shocked to find out that the disk was not the original one. Rather, it contained only one video of Sikander's mother. Sikander's mother self-filmed a video in which she reveals the truth that Ranchor was killed by Shamsher, and the twins were Ranchor's kids. Sikander arrives and tells how he escaped from the explosion, thanking to the timely intervention by Raghu Chacha (Sharat Saxena). He further reveals that he knew this secret for ten years and had been pretending to be loyal to Shamsher. Shamsher reveals that Yash is his real son. After a fight scene in the desert between Sikander and Yash, Sikander demolishes the entire army of Shamsher and makes both Yash and Shamsher surrender to Jessica who happens to be an Interpol officer. The arrested father-son duo are flown to their native village Handia.

Shamsher is seen bribing a police officer during jail proceedings, while Yash is seen to toning his body inside the prison cell. Sikander, reuniting with his twin siblings in Al-Shifa reveals the plot of handing over the original hard disk to Jessica. In conversation with the police officer in Handia Jail, Shamsher makes a metaphorical statement about the tiger of a new race.

• Anil Kapoor as Shamsher Singh/Robert D'Costa (RD) - A greedy man who after killing his brother Ranchor in Handia, heads to Cambodia and runs a weapons business. He tells fallaciously to his twin nephew and niece that they are his children. A former ally of ruthless businessman Ranvir Singh while in disguise of a private detective RD, he later parts from him and gives up his disguise to be with his brother's family while falsely claiming that he has given up bad company because of which he was formerly banished from home.

• Salman Khan as Sikander "Sikku" Singh - Son of Ranchor Singh, who's sent to Beijing where he falls in love with Interpol officer Jessica. He finds out that Shamsher, his uncle, betrayed and killed his father. He further finds out about his real siblings. For the next ten years he pretends to be loyal to Shamsher. He finally sends Shamsher and his real son Yash to prison.

• Jacqueline Fernandez as Jessica Gomes, an Interpol Officer - An Interpol officer who's sent to both Sikander and Yash by Suraj and Sanjana as part of their plan to destroy Sikander. Jessica is in the quest to find a hard disk containing videos of politicians.

• Bobby Deol as Yash Singh - The actual son of Shamsher, Yash wins Sikander's trust and never lets anyone know that he is Shamsher's son.

• Daisy Shah as Sanjana Singh - The sister of Sikander and Suraj, she is first fallaciously told by her uncle Shamsher that she is his daughter. She has contempt for Sikander.

• Saqib Saleem as Suraj Singh - The brother of Sikander and Sanjana, he, like his sister, is fallaciously told by her uncle Shamsher that he is his son and has hatred for Sikander. He is an angry young man.

• Sharat Saxena as Raghu Chacha - Shamsher's guard who gives Sikander the video of his mother telling true story of their family. He pretends to be Shamsher's closest. He finally saves Sikander's life by snatching from his hand, the pen that exploded killing him.

• Freddy Daruwala as Rana Vijay - A business rival of Singh family who many times attempts to kill its members. He finally joins Shamsher.

• Rajesh Sharma as Brijmohan
• Nishigandha Wad as Suraj and Sanjana's Mother
• Milind Gunaji as Ranchor Singh
• Narendra Jha as Khanna
• Anurag Arora as Vivek Singh, Vijender Singh's son
• Manav Vij as Vijender Singh

Development

In the year 2015, it was confirmed by director duo Abbas-Mustan that a third instalment in the Race franchise was being planned with Saif Ali Khan in lead role. In the year 2016 it was reported that producer Ramesh Taurani had approached Salman Khan for Race 3 but he refused to do the film and asked Turani to make some changes in the script. This report was confirmed to be true by Khan himself at the Trailer launch event of the film on 15 May 2018. In August 2017, it was reported that Khan had agreed to be a part of Race 3 on the condition that choreographer turned director Remo D'Souza would be the one to direct the film. In August 2017 it was reported that Saif Ali Khan had decided not to be a part of the film as he was opposed to the idea of him playing a parallel lead to Khan. After media reports surfaced about Katrina Kaif, Jacqueline Fernandez and Deepika Padukone being considered for the female lead opposite Khan, it was confirmed during August 2017 that Fernandez had been finalised for the role. To prepare for the action sequences that she had to do in the film, Jacqueline underwent extensive training in Mixed Martial Arts (MMA).

Filming

The shooting of the film began on 9 November 2017 at the Mehboob Studios in Mumbai. The filming of Race 3 moved to Bangkok in Thailand for its second schedule where they filmed a song and an action sequence, which was choreographed by Anal Arasu, at the Floating Market and Rose Garden as well as the jungles of Kanchanaburi Province. After finishing the shoot in Thailand, the production team reached Abu Dhabi for its next schedule. The shooting schedule in Abu Dhabi lasted for 35 days where filming was done at Emirates Palace, Yas Viceroy Abu Dhabi, The St Regis Abu Dhabi, Abu Dhabi National Exhibition Centre, Emirates Steel and the Liwa Desert. The action sequences in Abu Dhabi were choreographed by Tom Struthers, who has previously worked on movies like Inception, The Dark Knight and Dunkirk. For its next schedule the film unit moved to Kashmir and later on to Ladakh where Salman Khan and Jacqueline Fernandez filmed a romantic song.