Ganguly started his career making literary adaptations with strong female roles and themes of marital discord. For his second film Kora Kagaz his adapted Ashutosh Mukhopadhyay's story "Saat Paake Bandha", previously adapted into a Bengali film by the same name. Films female lead Jaya Bhaduri won Filmfare Best Actress Award for her role. His next film, Tapasya (1975) with Raakhee as lead was produced by Rajshri Productions, and was based story by Ashapurna Devi. Raakhee won the Filmfare Best Actress Award for her role He later adapted Sarat Chandra Chattopadhyay's novel Parineeta as Sankoch (1976), with Sulakshana Pandit and Jeetendra as leads. Humkadam again starring Raakhee, and made in 1980, was an adaptation of Satyajit Ray's Mahanagar.

His last major film was Anil Kapoor and Amrita Singh starrer Saaheb (1985). Later in his career, he shifted to making action and thriller films with Mithun Chakraborty and a few Bengali films. His last directorial venture was Bengali film Kiye Para Kiye Najara (1998) with Tapas Paul, and Debashree Roy. He died on 15 January 2016 at the age of 82.^[4]

• Half Ticket (1962) Assistant director
• Bheegi Raat (1965) Assistant director
• Mera Yaar Mera Dushman (1987)
• Kora Kagaz (1974)
• Tapasya (1975)
• Sankoch (1976)
• Trishna (1978)
• Khandaan (1979)
• Agreement (1980)
• Neeyat (1980)
• Aanchal (1980)
• Humkadam (1980)
• Karwat (1982)
• Kaun? Kaisey? (1983)
• Saheb (1985)
• Pyar Ke Kabil (1987)
• Sadak Chhap (1987)
• Balidan (Bolidan) (1990, Bengali)
• Dushman Devta (1991)
• Dil Ki Baazi (1993)
• Angaara (1996)
• Kiye Para Kiye Nijara (1998, Bengali)

His daughter, Rupali Ganguly is film and theatre actress.

His son, Vijay Ganguly is a director and choreographer

• National Film Award
  • 1974: Best Popular Film Providing Wholesome Entertainment: Kora Kagaz^[5]
  • 1975: Best Popular Film Providing Wholesome Entertainment: Tapasya^[6]