Jeena Sirf Merre Liye is about childhood friends Karan (Tusshar Kapoor) and Pinky (Puja) (Kareena Kapoor). Pinky and her father come to a hill station every year during Pinky's school break. Pinky looks forward to coming here for one reason: Karan. They get separated after Puja's father (Vijayendra Ghatge), a tycoon, goes back to the city. Karan gets adopted by a man also from the city. Puja's father sends her to his brother's house out of the country. Time passes and the two live with each other's memories. They try to find each other but are unable to.

She writes out her childhood story to find Karan and comes across Seema (Mallika Sherawat). Seema comes across Karan and believes him to be her boyfriend. She invited Karan to a party. Puja and Karan were introduced to each other. Later, Seema ask Karan to sing on stage. Karan sang the song "Jeena Sirf Merre Liye" that is when Puja realises that he is her childhood love. Meanwhile, the story that Puja wrote became very popular that Seema's boss wanted to make a film out of it. Seema read the story and realises that Karan and Puja were searching for each other. Seema goes to tell Karan. As he's going to find Puja he gets a call from his dad that his sister's wedding has been canceled.

The reason was Puja's father; he didn't approve of Puja and Karan. He gave Karan only two choices, to forget about his love and his sister's wedding will continue or he unites with Puja and his sister will not be accepted and ruin his family reputation. He immediately called Puja and said he's going to meet her. Puja, not knowing all this, have been waiting for this moment to come. When they met, Puja confesses her feelings to him. Karan said that he has been in love with her ever since they met at the party. Puja was hurt and angry at the same time. She ran away crying. Seema ask Puja for the climax of the story but Puja refuses and ask Seema to find someone else to write the climax. Seema sensed something is wrong. She goes and meet Karan's best friend and ask him to reveal any secrets they have been hiding. Seema find out the truth and tell Puja. Puja realises the truth and marries Karan in front of her father. He shoots Karan who survives. In the end they live happily ever after.

• Tusshar Kapoor as Karan Malhotra
• Kareena Kapoor as Puja (Pinky)
• Mallika Sherawat as Seema
• Kader Khan as Mahendra Malhotra
• Vijayendra Ghatge as Pooja's father
• Himani Shivpuri as Mrs. Malhotra
• Alok Nath as Mr. Khanna

The music of the movie was composed by the famous music director duo Nadeem–Shravan. All songs of the album became a major hit, with tracks like Jeena Sirf mere liye, Allah Allah and Ek baar toh India attaining special popularity.