The story revolves around two people who miss the last local train at 1:40 am and how it changes the course of their lives forever. The protagonist Nilesh (Abhay Deol) works in a call centre firm cultivated by the IT industry. Night shifts, booze, after office parties seem to be the order of the day. When Nilesh misses his last train from Kurla to Vikroli, he is rudely shoved off by a police constable who wants to keep the station clean from anti-social elements. Nowhere to go, he strolls outside for an auto-rickshaw, where he bumps into a beautiful damsel in distress, Madhu (Neha Dhupia), also wanting a ride to Vikhroli. As it turns out, the rickshaws are on strike due to a bomb blast earlier in the day at Ghatkopar. Nilesh and Madhu are forced to walk to the next rickshaw stand.

Nilesh stops by a local pub and is unable to resist his temptation to have a drink or two. He meets an old friend, Pat, who appears to have amassed a lot of money within a year through gambling. Knowing his expertise with the cards, Pat invites Nilesh to join him in the inner chambers to play with the high rollers. Upon some persuasion from Madhu, he gives in and gambles. Taking over Nilesh's turn, Pat loses all the money they have won to an underworld don. In the meantime, in his search for Madhu, Nilesh stumbles into the restroom where he finds Madhu apparently being forced upon by a local goon. He later learns that she was just plying her trade. A police encounter specialist, a religious but notorious south Indian don, a gay underworld don and the Mumbai red light underbelly too get involved. Starting the adventure with just Rs. 70 in his pocket, when he catches the first morning train home 2-½ hours later, he has Rs. 2.5 crores in his hands. How Nilesh lands up with this bounty and the girl by missing his train sums up this comic thriller.

• Abhay Deol as Nilesh Rastogi
• Neha Dhupia as Madhu/Mala
• Vinay Apte as Ponnappa
• Snehal Dabi as Habiba
• Ashwin Mushran as Mr. Bajaj
• Virendra Saxena as Rafiq
• Atul Srivastava as Hawaldar Tawde
• Manu Rishi
• Birdy as Emma
• Nawazuddin Siddiqui as Ponnappa's Brother (druggie in bar)
• Deepak Shirke as Mangesh Chilkey
• Ashok Samarth as Inspector Malvankar
• Amit Mistry as Patrick
• Kishor Kadam as Bhujang
• Sunita Rajwar
• Sanatan Modi
• Vivek Shauq

The album of Ek Chalis Ki Last Local was composed by Call Band.

• Laree Choote
• Laree Choote - Remix
• Ek Chauka
• Ek Chauka (Title Version)
• Akh
• Akh (Dance Version)
• Bheegi Bheegi Si
• Panga

Critical reception

Martin D’Souza of GlamSham gave the movie 3.5 stars out of 5, concluding that "If you loved BHEJA FRY, you will love this flick. Don’t be late for a ride on this last local! As for the producers, the cash register has just begun jingling."^[3]Taran Adarsh of Bollywood Hungama gave the movie 3 stars out of 5, saying that "EK CHALIS KI LAST LOCAL is a decent fare that stands out for a few individualistic episodes in the narrative. At the box-office, the film caters to the multiplex audience mainly, especially big city multiplexes. Business in Mumbai multiplexes should be better due to its Mumbaiya flavor."^[4] Ashok Nayak of NowRunning gave the movie 2.5 stars out of 5, stating that "Ek Chalis Ki Last Local has shades of brilliance but 10 to 15 minutes can be easily trimmed off from the movie for better impact. Repeating and unnecessary stretching of scenes are repelling."^[5]

An sequel titled Gyaraah Chalis Ki Last Metro was announced in the early 2010s. It was announced that the film would feature Vivek Oberoi opposite Mallika Sherawat in lead roles. In early 2012, it was announced that the idea of an sequel had been slightly changed. The project would still be released with the same cast & crew, however it will not be noted as an sequel to Ek Chalis Ki Last Local. In October 2012, the film released as Kismet Love Paisa Dilli.