Powell made his List A debut in January 2015, playing for the Combined Campuses against Guyana in the 2014–15 Regional Super50. He took 3/20 and scored 31 runs on debut, and was named man of the match. Powell made his first-class debut in the 2015–16 Regional Four Day Competition, playing for Jamaica against Guyana. For the 2015–16 Regional Super50, he returned to the Combined Campuses. In his team's final two matches, he scored twin half-centuries, 71 against the Windward Islands and 63 not out against Guyana. He played a key role in Jamaica's march to the final of the 2016-17 Regional Super50. In the semi-final against Trinidad and Tobago, he smashed 95 runs from 45 balls (including 9 sixes and 6 fours), before taking 5-36; these were both career-best List A performances, leading to him being named man-of-the-match. He was then selected by the Jamaica Tallawahs in the 6th round of the 2017 CPL player draft.

He made his One Day International (ODI) debut in the second match of the tri-series, against Sri Lanka.^[8] He made his Twenty20 International (T20I) debut for the West Indies against Pakistan on 26 March 2017.^[9]

In February 2018, the International Cricket Council (ICC) named Powell as one of the ten players to watch ahead of the 2018 Cricket World Cup Qualifier tournament.^[10] Following the conclusion of the Cricket World Cup Qualifier tournament, the ICC named Powell as the rising star of the West Indies' squad.^[11]

In February 2017, he was bought by the Kolkata Knight Riders team for the 2017 Indian Premier League for 30 lakhs.^[12] Unfortunately, he did not get a game for the entirety of the season.