Film and television

• Michael Bailey Smith (born 1957), American film and television actor
• Mike Smith (actor) (born 1972), Canadian who portrayed Bubbles on Trailer Park Boys
• Michael Smith (director), American film and television series director
• Valentine Michael Smith, chief character in Stranger in a Strange Land

Music

• Michael Joseph Smith (born 1938), American classical composer and pianist
• Mike Smith (singer-songwriter) (born 1939), American singer-songwriter
• Michael Peter Smith (born 1941), American songwriter and performer
• Mike Smith (Dave Clark Five) (1943–2008), English singer-songwriter
• Michael S. Smith (1946–2006), American jazz drummer
• Mike Smith (jazz saxophonist) (born 1957), American jazz saxophonist
• Michael W. Smith (born 1957), American Christian singer and musician
• Mike Smith (drummer) (born 1970), American drummer for Suffocation
• Mike Smith (guitarist) (born 1973), American guitarist for Limp Bizkit
• Mike Smith (record producer), Cuban American record producer and musician
• Mike Smith (saxophonist), English saxophonist for The Ailerons
• Mike Smith (born 1947), Welsh saxophonist (Amen Corner)

Other entertainment

• M. G. Smith (Michael G. Smith, 1921–1993), Jamaican poet and social anthropologist
• Michael Smith (poet) (1942–2014), Irish poet and translator
• Michael Smith (author) (born 1946), British author and journalist
• Michael Smith (performance artist) (born 1951), American performance artist
• Mikey Smith (1954–1983), Jamaican dub poet and performance artist
• Michael Marshall Smith (born 1965), English novelist and screenwriter
• Michael Smith (chef) (born 1966), American born celebrity chef residing in Canada
• Michael V. Smith, Canadian novelist, poet and filmmaker
• Mike Prestwood Smith, sound mixer
• Mike Smith (A&R man), managing director of Columbia Records UK

• M. Hoke Smith (1855–1931), American politician
• Michael Smith (Irish politician) (born 1940), Irish politician
• Carl Michael Smith (born 1944), known as Mike, former Oklahoma Secretary of Energy
• Mike Smith (Louisiana politician) (born 1948), former Louisiana state senator from Winnfield
• Michael Keith Smith (1953–2010), chairman of United Kingdom pressure group, the Conservative Democratic Alliance
• Michael K. Smith (Illinois politician) (1966–2014), former member of the Illinois House of Representatives
• Michael K. Smith (Vermont), secretary of human services for the state of Vermont, 2006–2008
• Mike Smith (Nova Scotia politician), mayor of Colchester County, Nova Scotia, Canada
• Michael Adye Smith (1886–1965), Australian politician

• Michael Townsend Smith (born 1935), theatre critic, music and dance critic, and playwright
• Michael Smith (newspaper reporter) (born 1952), reporter for the Sunday Times
• Mike Smith (broadcaster) (1955–2014), English television and radio presenter
• Michael Smith (Irish journalist) (born 1965)
• Michael Smith (writer) (born 1976), English writer and broadcaster
• Michael Smith (sports reporter) (born 1979), American sports reporter for The Boston Globe and ESPN
• Michael Smith (American journalist), American journalist for Bloomberg News
• Michael David Smith, American sportswriter
• Michael Smith (PR consultant), PR consultant and former editor of The Age

• Michael Percival Smith (1924–2013), Archdeacon of Maidstone, 1979 until 30 September 1989
• Michael Smith (bishop) (born 1940), Catholic Bishop of Meath, Ireland
• Michael G. Smith (born 1955), Episcopal Bishop of North Dakota, United States

• Michael Smith (chemist) (1932–2000), Canadian Nobel Prize–winning chemist
• Michael J. Smith (astronaut) (1945–1986), American astronaut
• Michael F Smith (born 1948), Anglo-American computer scientist and businessman
• Michael E. Smith (born 1953), American archaeologist and Mesoamerica scholar
• Michael D. Smith (computer scientist), Dean of the Faculty of Arts and Sciences at Harvard University
• Michael D. Smith (economist), information technology and marketing professor
• C. Michael Smith (born 1950), clinical psychologist and scholar

American football

• Mike Smith (American football coach) (born 1959), former head coach of the NFL Atlanta Falcons
• Mike Smith (linebacker) (born 1981), former NFL linebacker, current co-defensive coordinator for the Texas Tech Red Raiders
• Michael Smith (running back) (born 1988), American football running back who is currently a free agent
• Michael Smith (American football coach), American football coach in the United States

Association football

• Mike Smith (footballer, born 1935) (1935–2013), English defender for Derby County and Bradford City
• Mike Smith (football manager) (born 1937), manager of Egypt and Wales national football teams and of Hull City
• Mick Smith (footballer) (born 1958), English defender who played for Wimbledon and others
• Michael Smith (footballer, born 1988), Northern Irish footballer who plays for Heart of Midlothian
• Michael Smith (footballer, born 1991), English professional footballer who plays for Rotherham United

Baseball

• Mike Smith (1890s outfielder) (1868–1945), MLB outfielder from 1886–1901
• Mike Smith (1920s outfielder) (1904–1981), MLB outfielder who played in the 1926 season
• Mike Smith (1984–89 pitcher) (born 1961), National League pitcher from 1984–89
• Mike Smith (1989–1990 pitcher) (born 1963), American League pitcher from 1989–90
• Mike Smith (infielder) (born 1969), Rotary Smith Award winner
• Mike Smith (2000s pitcher) (born 1977), MLB pitcher in the 2000s

Basketball

• Mike Smith (basketball, born 1963), former professional basketball player from the University of South Carolina-Spartanburg
• Michael Smith (basketball, born 1965), former BYU and Boston Celtics player, and former Los Angeles Clippers television and radio commentator
• Michael Smith (basketball, born 1972), former NBA player from Washington, D.C.
• Mike Smith (basketball, born 1976), professional basketball player from West Monroe, Louisiana
• Mike Smith (basketball, born 1987), professional basketball player from East Tennessee State University

Cricket

• M. J. K. Smith (born 1933), English cricketer and rugby union player
• Michael J. Smith (cricketer) (1942–2004), cricketer who played for Middlesex CCC and England
• Mike Smith (Scottish cricketer) (born 1966), Scottish cricketer
• Andrew