Desai, who started her career at an early age, got her first break in Ravan on Zee TV followed by Meet Mila De Rabba on Sony TV and started acting in the show Uttaran on Colors from 2008. In March 2012 she opted out of Uttaran as she didn't believe she could portray an older role after the leap. On 7 November 2012, she returned to Uttaran in positive shades.

Desai has worked in other serials including Pari Hoon Main. She has also done episodes for Ssshhhh...Phir Koi Hai. She has featured in reality shows such as Comedy Circus, Maha Sangram, Zara Nachke Dikha, Crime Patrol, Big Money, Kitchen Champion Season 2, Comedy Ka Maha Muqabala and Jhalak Dikhhla Ja.

Desai has took part in several dance and reality TV shows including Jhalak Dikhhla Jaa 5 which aired on Colors TV. On the show she spoke about her miscarriage and other contestant felt that it was all done for sympathy.^[8][9] She also appeared on the Shekhar Suman hosted show Movers and Shakers.^[10]

In 2015, Desai participated in Fear Factor: Khatron Ke Khiladi but was eliminated. Later she was brought back on the show as a wild card. She then participated in Nach Baliye 7 with her spouse Nandish Sandhu and they became finalists. Desai has also appeared on Ishq Ka Rang Safed and Adhuri Kahaani Hamari.

Desai married her co-star from Uttaran, Nandish Sandhu, on 12 February 2012, in Dholpur.^[11] In 2014 they separated, and in 2015, the couple filed for divorce after almost four years of marriage.^[12]

Bhojpuri movies

Bollywood films

Assamese films

Gujarati films

• Bhakti Rathod
• Prachi Desai