In late 2010, Kajal Aggarwal announced that Nisha would make her acting debut in Telugu films. Nisha had been travelling with her sister to the shooting sets and soon got noticed. Her first Telugu film, she said, happened after the director saw stills of her in a magazine. Her first film was the romantic drama, Yemaindi Ee Vela, which was a box office success. Her performance was praised by critics. Her next film was Solo, which released in late 2011 and featured her as a medical college student, with a reviewer from Rediff stating that she "proves her acting talents in the second half, especially the climax".

She made her debut in Tamil with the film Ishtam (2012), a remake of Yemaindi Ee Vela, which was a box office failure.^[10] She appeared as a "chatpata village girl" in 2013 opposite Aadi and Bhavna Ruparel in Sukumarudu.^[11] Later that year she starred in a film titled Saradaga Ammayitho that saw her pairing with her Yemaindi Ee Vela co-star Varun Sandesh again. In 2014, she entered into the Malayalam film industry with Bhaiyya Bhaiyya, playing Angel, an "educated and headstrong girl",^[5] who is the daughter of an ex-minister.^[12] She has been signed up for another Malayalam film, Cousins.^[13]

Nisha Agarwal married a Mumbai-based businessman Karan Valecha on December 28, 2013.^[14][15]

• Bhavna Ruparel
• Sukumarudu