Sanusha was born to Santhosh and Usha in Nileshwaram, state of Kerala, India. She has one younger brother Sanoop Santhosh, who is a child artist, known for his acting in Philips and the Monkey Pen. She hails from Nileshwaram, Kasargod District, Kerala, she has studied at Sreepuram School, Kannur. After doing her graduation in B. com in S.N. College, Kannur she did MA sociology at St Theresa's college.

After performing in TV serials, Sanusha started her film career in 2000 at the age of 5 with the movie Dada Sahib. She became a star in Malayalam films as baby Sanusha giving stellar performances in "meesamadhavan", "kazhcha", "mambazhakalam" etc. She twice won the Kerala state award for best child actress. She debuted as a heroine in tamil film Nalai Namathey in a glamorous role followed by demure roles in Renigunta, Nandi and Eththan. In Malayalam she debuted as heroine opposite Dileep in Mr.marumakan. In tamil film "Alex Pandian" she did an oomphy item song with Karthi. Although she is able to do both glamorous as well as quality roles, she is yet to achieve the heights she reached as a child actress.

Sanusha won a Special Jury Mention at the 2013 Kerala State Film Awards for Zachariayude Garbhinikal..

Kerala State Film Award

• 2004 – Best Female Child Artist: Kaazhcha
• 2014 – Special Mention: Zachariayude Garbhinikal^[4]

61st Filmfare Awards South

• Nominated -Filmfare Awards South for Best Supporting Actress for Zachariayude Garbhinikal

3rd South Indian International Movie Awards

• 3rd South Indian International Movie Awards for Best Actress in a Supporting Role – Zachariayude Garbhinikal

Kerala State Television Award

• 2006 – Best child Artist-Violin

Asianet Television awards

• 2007-Best child Actress – Unniyarcha
• 2008-Best Child Actress – Amma Manassu^[5]

Asianet Film Award -Best Child Artist Female – Kaazhcha

• Amma Manassu
• Unniyarcha
• Orma
• Violin
• Swapnam
• Fnsa The Great